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William J. McCarthy, PhD; Tony Kuo, MD, MSHS

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Several articles in the Archives^1-3 examined facets of the relationship between physical activity, dietary choices, obesity risk, and risk of diabetes mellitus. We believe that taken together, the articles support the importance of regular exercise for affecting satiety and diabetes risk. Tinker et al¹ concluded that 3 randomized controlled diabetes prevention trials reduced diabetes risk, whereas the Women's Health Initiative (WHI) Dietary Modification Trial (DMT) did not. This is in part because these previous trials had included physical activity in their interventions whereas the WHI DMT did not.

One reason that could explain why physical activity would be disproportionately important in modifying diabetes risk is that it is an important mediator of weight loss, which is more highly related to reducing diabetes risk than the macronutrient composition of the diet. Not surprisingly, the mean weight loss in the intervention arm of the . . . [Full Text of this Article]

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