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COMMENTS AND OPINIONS
Support for Benefit of Physical Activity on Satiety, Weight Control, and Diabetes Risk—Reply
Nita Forouhi, FFPH, PhD;
Anne-Helen Harding, PhD;
Kay-Tee Khaw, FRCP;
Sheila Bingham, PhD;
Nicholas Wareham, FRCP, PhD
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In reply
We are pleased that Hercberg and colleagues highlighted the broad agreement between their post hoc analysis of the SU.VI.MAX trial data1 and our findings from the European Prospective Investigation of Cancer (EPIC)–Norfolk cohort,2 with an inverse association between baseline plasma vitamin C concentration and follow-up fasting glucose level in their study1 and with risk of incident diabetes in our study.2 However, there was no change in follow-up fasting glucose level with combined antioxidant supplementation including 120 mg/d of ascorbic acid in the SU.VI.MAX trial, a discrepancy often seen between observational and trial evidence for nutritional factors.3 Two issues emerge: one relates to methodological considerations comparing questionnaire-based fruit and vegetable intake and a biomarker of that intake and the other issue relates to causal inference, ie, whether vitamin C concentration per se . . . [Full Text of this Article]
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