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André J. Scheen, MD, PhD

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Wildman et al¹ reported a high prevalence (23.5%) of clustering of cardiometabolic abnormalities in normal-weight adults among US subjects. The report of an 8.6% prevalence of metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III) definition in normal-weight individuals in their cohort allows for comparison with previous data in adults with a BMI lower than 25. In US National Health and Nutrition Examination Survey (NHANES) III, the overall prevalence of metabolic syndrome in such individuals averaged 4.6% in men and 6.2% in women,² with waist circumference having a major impact (9.7% in men and 12.8% in women with increased waist vs 5.7% and 2.9%, respectively, in those with a normal waist size).³ It is interesting to compare the US data collected in 2 successive NHANES populations. Indeed, according to the same ATP-III criteria, the prevalence of metabolic syndrome in . . . [Full Text of this Article]

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