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Giuseppe Lippi, MD; Martina Montagnana, MD; Giovanni Targher, MD; Gian Cesare Guidi, MD

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den Elzen et al¹ recently showed that anemia in a general population of very elderly individuals is associated with folate deficiency but not with vitamin B₁₂ deficiency. Because the prediction of anemia is an important aspect of the practice of hematology, especially in elderly individuals, we retrospectively analyzed the results of hemoglobin, folate, and vitamin B₁₂ measurements performed on a cohort of unselected subjects older than 85 years, who were referred to our laboratory by general practitioners for routine diagnostic checkup over the past 2 years. Based on the larger Scripps-Kaiser database, anemia was defined as a hemoglobin concentration lower than 13.2 g/dL (to convert to grams per liter, multiply by 10) in older men and lower than 12.2 g/dL in older women, respectively.² Cumulative results were retrieved from the database of our Laboratory Information System for . . . [Full Text of this Article]

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