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Comment on "Effect of Aspirin on Vascular and Nonvascular Outcomes"

Samia Mora, MD, MHS

Arch Intern Med. Published online January 9, 2012. doi:10.1001/archinternmed.2011.626

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The use of aspirin in medicine dates at least as far back as Hippocrates who found analgesic effects for the extract (salicin) of white willow bark.¹ Aspirin irreversibly inactivates platelet cyclooxygenase, preventing platelets from synthesizing thromboxane A₂, a potent vasoconstrictor and promoter of platelet aggregation. Aspirin also has anti-inflammatory and vasodilatory effects that may be important.

Aspirin use is recommended for the secondary prevention of cardiovascular disease (CVD) in patients with prior CVD because it decreases the risk of CVD events and mortality in clinical trials of men and women with CVD.² The 2009 meta-analysis by the Antithrombotic Trialists' (ATT) collaboration analyzed individual participant data from 16 secondary prevention trials (17 000 individuals; 3306 CVD events).² Compared with placebo, aspirin resulted in an approximate 10% relative risk (RR) reduction of CVD mortality and total mortality and an approximate 20% RR reduction of CVD events (absolute risk . . . [Full Text of this Article]

AUTHOR INFORMATION
Author Affiliation: Divisions of Cardiovascular Disease and Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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Effect of Aspirin on Vascular and Nonvascular Outcomes: Meta-analysis of Randomized Controlled Trials
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