Figure 2. Estimated marginal means (SEs) of mood scores before and after 8, 24, 40, and 52 weeks of energy restriction with a low-carbohydrate, high-fat (LC) diet or a high carbohydrate, low-fat (LF) diet. Beck Depression Inventory score (A), Spielberger State-Trait Anxiety Inventory score (B), and the Profile of Mood States subscales: anger-hostility (C), depression-dejection (D), tension-anxiety (E), fatigue-inertia (F), vigor-activity (G), confusion-bewilderment (H), and total mood disturbance score (I). The asterisk indicates that the score is significantly higher compared with the LF diet (P < .05).