 |
|
Coffee, Cirrhosis, and Transaminase Enzymes
Arthur L. Klatsky, MD;
Cynthia Morton, MD;
Natalia Udaltsova, PhD;
Gary D. Friedman, MD
Arch Intern Med. 2006;166:1190-1195.
Background A minority of persons at risk develop liver cirrhosis, but knowledge of risk modulators is sparse. Several reports suggest that coffee drinking is associated with lower cirrhosis risk.
Methods We studied 125 580 multiethnic members of a comprehensive prepaid health care plan without known liver disease who supplied baseline data at voluntary health examinations from 1978 to 1985. Subsequently, through 2001, 330 of them were diagnosed with liver cirrhosis. Review of medical records confirmed the diagnosis of cirrhosis and ascertained probable etiology. The association of coffee drinking with cirrhosis was estimated by Cox proportional hazards models with 7 covariates. We also did a cross-sectional analysis of baseline aspartate aminotransferase and alanine aminotransferase levels, studied by logistic regression.
Results In the cohort study, relative risks of alcoholic cirrhosis (199 subjects) for coffee drinking (vs none) were less than 1 cup per day, 0.7 (95% confidence interval [CI], 0.4-1.1); 1 to 3 cups, 0.6 (95% CI, 0.4-0.8; P<.001); and 4 or more cups, 0.2 (95% CI, 0.1-0.4; P<.001). For 131 subjects with nonalcoholic cirrhosis, relative risks were less than 1 cup, 1.2 (95% CI, 0.6-2.2); 1 to 3 cups, 1.3 (95% CI, 0.8-2.1); and 4 or more cups, 0.7 (95% CI, 0.4-1.3). These relative risks for coffee drinking were consistent in subsets. Tea drinking was unrelated to alcoholic or nonalcoholic cirrhosis. In the cross-sectional analyses, coffee drinking was related to lower prevalence of high aspartate aminotransferase and alanine aminotransferase levels; for example, the odds ratio of 4 or more cups per day (vs none) for a high aspartate aminotransferase level was 0.5 (95% CI, 0.4-0.6; P<.001) and for a high alanine aminotransferase level, 0.6 (95% CI, 0.6-0.7; P<.001), with stronger inverse relations in those who drink large quantities of alcohol.
Conclusion These data support the hypothesis that there is an ingredient in coffee that protects against cirrhosis, especially alcoholic cirrhosis.
Author Affiliations: Divisions of Research (Drs Klatsky, Udaltsova, and Friedman) and Gastroenterology (Dr Morton), Department of Medicine, Kaiser Permanente Medical Care Program, Oakland, Calif.
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
RELATED LETTERS
Coffee and Cirrhosis: Active Ingredients?
Joe A. Vinson
Arch Intern Med. 2006;166(21):2404-2405.
EXTRACT
| FULL TEXT
Coffee and Cirrhosis: Active Ingredients?—Reply
Arthur L. Klatsky, Cynthia Morton, Natalia Udaltsova, and Gary D. Friedman
Arch Intern Med. 2006;166(21):2405.
EXTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Current status of novel antifibrotic therapies in patients with chronic liver disease
Cohen-Naftaly and Friedman
Therapeutic Advances in Gastroenterology 2011;4:391-417.
ABSTRACT
Effect of moderate alcohol consumption on liver enzymes increases with increasing body mass index
Alatalo et al.
Am J Clin Nutr 2008;88:1097-1103.
ABSTRACT
| FULL TEXT
Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis
Peng et al.
FASEB J. 2008;22:2263-2272.
ABSTRACT
| FULL TEXT
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Friedman
Physiol. Rev. 2008;88:125-172.
ABSTRACT
| FULL TEXT
Coffee and Cirrhosis: Active Ingredients?
Vinson
Arch Intern Med 2006;166:2404-2405.
FULL TEXT
|
