 |
|
Mediterranean Dietary Pattern and Prediction of All-Cause Mortality in a US PopulationResults From the NIH-AARP Diet and Health Study
Panagiota N. Mitrou, PhD;
Victor Kipnis, PhD;
Anne C. M. Thiébaut, PhD;
Jill Reedy, PhD;
Amy F. Subar, PhD;
Elisabet Wirfält, PhD;
Andrew Flood, PhD;
Traci Mouw, MPH;
Albert R. Hollenbeck, PhD;
Michael F. Leitzmann, MD, DrPH;
Arthur Schatzkin, MD, DrPH
Arch Intern Med. 2007;167(22):2461-2468.
Background The Mediterranean diet has been suggested to play a beneficial role for health and longevity. However, to our knowledge, no prospective US study has investigated the Mediterranean dietary pattern in relation to mortality.
Methods Study participants included 214 284 men and 166 012 women in the National Institutes of Health (NIH)-AARP (formerly known as the American Association of Retired Persons) Diet and Health Study. During follow-up for all-cause mortality (1995-2005), 27 799 deaths were documented. In the first 5 years of follow-up, 5985 cancer deaths and 3451 cardiovascular disease (CVD) deaths were reported. We used a 9-point score to assess conformity with the Mediterranean dietary pattern (components included vegetables, legumes, fruits, nuts, whole grains, fish, monounsaturated fat–saturated fat ratio, alcohol, and meat). We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) using age- and multivariate-adjusted Cox models.
Results The Mediterranean diet was associated with reduced all-cause and cause-specific mortality. In men, the multivariate HRs comparing high to low conformity for all-cause, CVD, and cancer mortality were 0.79 (95% CI, 0.76-0.83), 0.78 (95% CI, 0.69-0.87), and 0.83 (95% CI, 0.76-0.91), respectively. In women, an inverse association was seen with high conformity with this pattern: decreased risks that ranged from 12% for cancer mortality to 20% for all-cause mortality (P = .04 and P < .001, respectively, for the trend). When we restricted our analyses to never smokers, associations were virtually unchanged.
Conclusion These results provide strong evidence for a beneficial effect of higher conformity with the Mediterranean dietary pattern on risk of death from all causes, including deaths due to CVD and cancer, in a US population.
Author Affiliations: Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (Drs Mitrou, Thiébaut, Leitzmann, and Schatzkin and Ms Mouw), Biometry Research Group, Division of Cancer Prevention (Dr Kipnis), and Applied Research Branch, Division of Cancer Control and Population Sciences (Drs Reedy and Subar), National Cancer Institute, Bethesda, Maryland; Department of Clinical Sciences, Lund University, Malmö, Sweden (Dr Wirfält); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (Dr Flood); and AARP, Washington, DC (Dr Hollenbeck). Dr Mitrou is now with the Department of Public Health and Primary Care, University of Cambridge, Cambridge, England.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati
What's this?
RELATED LETTER
Mediterranean Diet and Mortality in a US Population
Nikolaos Scarmeas, Jose A. Luchsinger, Richard Mayeux, Nicole Schupf, and Yaakov Stern
Arch Intern Med. 2008;168(16):1823-1824.
EXTRACT
| FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Patterns of Recommended Dietary Behaviors Predict Subsequent Risk of Mortality in a Large Cohort of Men and Women in the United States
Kant et al.
J. Nutr. 2009;139:1374-1380.
ABSTRACT
| FULL TEXT
The Development of the Mediterranean-Style Dietary Pattern Score and Its Application to the American Diet in the Framingham Offspring Cohort
Rumawas et al.
J. Nutr. 2009;139:1150-1156.
ABSTRACT
| FULL TEXT
Nuts and health outcomes: new epidemiologic evidence
Sabate and Ang
Am. J. Clin. Nutr. 2009;89:1643S-1648S.
ABSTRACT
| FULL TEXT
A Combined Healthy Lifestyle Score and Risk of Pancreatic Cancer in a Large Cohort Study
Jiao et al.
Arch Intern Med 2009;169:764-770.
ABSTRACT
| FULL TEXT
Mediterranean Diet and Incidence of and Mortality From Coronary Heart Disease and Stroke in Women
Fung et al.
Circulation 2009;119:1093-1100.
ABSTRACT
| FULL TEXT
Potential Mechanisms Underpinning the Nutritional Modulation of Periodontal Inflammation
Chapple
Journal of the American Dental Association 2009;140:178-184.
ABSTRACT
| FULL TEXT
Heart Disease and Stroke Statistics--2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
WRITING GROUP MEMBERS et al.
Circulation 2009;119:e21-e181.
FULL TEXT
The Mediterranean Diet and Your Health
Brill
AMERICAN JOURNAL OF LIFESTYLE MEDICINE 2009;3:44-56.
ABSTRACT
Fruit and vegetable intake and risk of cancer: a prospective cohort study
George et al.
Am. J. Clin. Nutr. 2009;89:347-353.
ABSTRACT
| FULL TEXT
Effect of a Mediterranean Diet Supplemented With Nuts on Metabolic Syndrome Status: One-Year Results of the PREDIMED Randomized Trial
Salas-Salvado et al.
Arch Intern Med 2008;168:2449-2458.
ABSTRACT
| FULL TEXT
Association between adherence to the Mediterranean diet and oxidative stress
Dai et al.
Am. J. Clin. Nutr. 2008;88:1364-1370.
ABSTRACT
| FULL TEXT
Mediterranean dietary patterns and chronic diseases
Esposito and Giugliano
Am. J. Clin. Nutr. 2008;88:1179-1180.
FULL TEXT
Mediterranean Diet and Mortality in a US Population
Scarmeas et al.
Arch Intern Med 2008;168:1823-1824.
FULL TEXT
Management of Peripheral Arterial Disease
Steffen et al.
Diabetes Spectr. 2008;21:171-177.
ABSTRACT
| FULL TEXT
Adherence to Mediterranean diet and risk of developing diabetes: prospective cohort study
Martinez-Gonzalez et al.
BMJ 2008;336:1348-1351.
ABSTRACT
| FULL TEXT
Dietary Strategies for Improving Post-Prandial Glucose, Lipids, Inflammation, and Cardiovascular Health
O'Keefe et al.
J Am Coll Cardiol 2008;51:249-255.
ABSTRACT
| FULL TEXT
|
