• Online Features  This Article  • Full text  • PDF  • eTable  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (28)  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in this journal  Topic Collections  • Aging/ Geriatrics  • Neurology  • Dementias  • Public Health  • Exercise  • Alert me on articles by topic  Social Bookmarking   What's this?

The INVADE Study

Thorleif Etgen, MD; Dirk Sander, MD; Ulrich Huntgeburth, MD; Holger Poppert, MD; Hans Förstl, MD; Horst Bickel, PhD

Arch Intern Med. 2010;170(2):186-193.

Background  Data regarding the relationship between physical activity and cognitive impairment are limited and controversial. We examined whether physical activity is associated with incident cognitive impairment during follow-up.

Methods  As part of a community-based prospective cohort study in southern Bavaria, Germany, 3903 participants older than 55 years were enrolled between 2001 and 2003 and followed up for 2 years. Physical activity (classified as no activity, moderate activity [<3 times/wk], and high activity [3 times/wk]), cognitive function (assessed by the 6-Item Cognitive Impairment Test), and potential confounders were evaluated. The main outcome measure was incident cognitive impairment after 2 years of follow-up.

Results  At baseline, 418 participants (10.7%) had cognitive impairment. After a 2-year follow-up, 207 of 3485 initially unimpaired subjects (5.9%) developed incident cognitive impairment. Compared with participants without physical activity, fully adjusted multiple logistic regression analysis showed a significantly reduced risk of incident cognitive impairment after 2 years for participants with moderate or high physical activity at baseline (odds ratio [OR], 0.57; 95% confidence interval [CI], 0.37-0.87 [P = .01]; and OR, 0.54; 95% CI, 0.35-0.83 [P = .005]; respectively). Further subanalysis including participants (n = 2029) without functional impairment and without prodromal phase of dementia resulted in an even higher reduction of risk of incident cognitive impairment for participants with moderate or high physical activity (OR, 0.44; 95% CI, 0.24-0.83 [P = .01]; and OR, 0.46; 95% CI, 0.25-0.85 [P = .01]; respectively) compared with no activity.

Conclusion  Moderate or high physical activity is associated with a reduced incidence of cognitive impairment after 2 years in a large population-based cohort of elderly subjects.

Author Affiliations: Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany (Drs Etgen, Förstl, and Bickel); Department of Neurology, Klinikum Traunstein, Traunstein, Germany (Dr Etgen); Department of Neurology, Technische Universität München, Munich, Germany (Drs Sander and Poppert); Department of Neurology, Medical Park Hospital, Bischofswiesen, Germany (Dr Sander); and INVADE Study Group, Ebersberg, Germany (Dr Huntgeburth).

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLES

Evidence Regarding the Benefits of Physical Exercise
Jeff Williamson and Marco Pahor
Arch Intern Med. 2010;170(2):124-125.
EXTRACT | FULL TEXT  

Resistance Training and Executive Functions: A 12-Month Randomized Controlled Trial
Teresa Liu-Ambrose, Lindsay S. Nagamatsu, Peter Graf, B. Lynn Beattie, Maureen C. Ashe, and Todd C. Handy
Arch Intern Med. 2010;170(2):170-178.
ABSTRACT | FULL TEXT  

Exercise Effects on Bone Mineral Density, Falls, Coronary Risk Factors, and Health Care Costs in Older Women: The Randomized Controlled Senior Fitness and Prevention (SEFIP) Study
Wolfgang Kemmler, Simon von Stengel, Klaus Engelke, Lothar Häberle, and Willi A. Kalender
Arch Intern Med. 2010;170(2):179-185.
ABSTRACT | FULL TEXT  

Physical Activity at Midlife in Relation to Successful Survival in Women at Age 70 Years or Older
Qi Sun, Mary K. Townsend, Olivia I. Okereke, Oscar H. Franco, Frank B. Hu, and Francine Grodstein
Arch Intern Med. 2010;170(2):194-201.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Physical Activity Moderates Effects of Stressor-Induced Rumination on Cortisol Reactivity
Puterman et al.
Psychosom. Med. 2011;73:604-611.
ABSTRACT | FULL TEXT  

Physical Activity and Cognition in Women With Vascular Conditions
Vercambre et al.
Arch Intern Med 2011;171:1244-1250.
ABSTRACT | FULL TEXT  

Muscles and their myokines
Pedersen
J. Exp. Biol. 2011;214:337-346.
ABSTRACT | FULL TEXT  

What's new in treating older adults?
MESSINGER-RAPPORT
Cleveland Clinic Journal of Medicine 2010;77:770-790.
ABSTRACT | FULL TEXT  

Reducing Iatrogenic Risks: ICU-Acquired Delirium and Weakness--Crossing the Quality Chasm
Vasilevskis et al.
Chest 2010;138:1224-1233.
ABSTRACT | FULL TEXT  

Alzheimer disease prevention: Focus on cardiovascular risk, not amyloid?
GELDMACHER
Cleveland Clinic Journal of Medicine 2010;77:689-704.
ABSTRACT | FULL TEXT  

Moderate or high physical activity lowers the risk of cognitive impairment in older people
McCusker
Evid. Based Ment. Health 2010;13:73-73.
FULL TEXT  

All you need to read in the other general journals
BMJ 2010;340:c580-c580.
FULL TEXT  

Evidence Regarding the Benefits of Physical Exercise
Williamson and Pahor
Arch Intern Med 2010;170:124-125.
FULL TEXT