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WILFRED R. EHRMANTRAUT, M.D.; JAMES G. SHEA, M.D.; HOWARD E. TICKTIN, M.D.; JOSEPH F. FAZEKAS, M.D.

AMA Arch Intern Med. 1957;100(1):66-69.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Promazine, a new phenothiazine derivative, appears to offer considerable promise in the control of patients with increased psychomotor activity ^1,2 as well as assisting in the management of patients with various medical emergencies.³ The exact physiological mechanism by which this drug exerts its effects is not known; however, previous studies⁴ have shown chlorpromazine, a somewhat similar phenothiazine derivative, to have no demonstrable effects upon total cerebral hemodynamics and oxygen utilization. It was nevertheless considered worth while to determine whether this was also true of promazine. In addition, this study afforded the opportunity to examine the clinical and quantitative cerebral effects of methylphenidate hydrochloride (an analeptic drug) alone and upon subjects to whom promazine had been previously administered.

Methods

The subjects of the present study were 21 hospital patients who had been admitted for a variety of acute illnesses but were convalescent and otherwise in reasonably good condition. They . . . [Full Text PDF of this Article]

Author Affiliations
Washington, D. C.

From the George Washington and Georgetown University Medical Divisions, District of Columbia General Hospital.

Footnotes
Submitted for publication Sept. 14, 1956.

This investigation was supported in part by a research grant (PHS B-178) from the National Institute of Neurological Diseases and Blindness of the National Institutes of Health, Public Health Service.

The promazine (Sparine) used in this study was supplied by Wyeth Laboratories, Inc., Philadelphia. The methylphenidate hydrochloride (Ritalin) used in this study was supplied by Ciba Pharmaceutical Products, Inc., Summit, N. J.

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