This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (10)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

III. On the Diagnostic Value of Urinary Lipase

MARTIN M. NOTHMAN, M.D.; JOSEPH H. PRATT, M.D.; ALLAN D. CALLOW, M.D.

AMA Arch Intern Med. 1957;100(2):221-227.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In the first two papers of this series ¹ we were able to show that a fat-splitting enzyme is present regularly in the urine of dogs. We presented the following observations as evidence that the fat-splitting enzyme is of pancreatic origin: 1. Injection of methacholine (Mecholyl) and secretin in dogs increases the amount of the fat-splitting enzyme in the urine. 2. Removal of the pancreas causes an immediate disappearance of the enzyme in the urine. 3. Ligation of the pancreatic ducts leads to a marked rise in the excreted amount of the enzyme followed slowly by a decrease to rather low values. 4. Ligation of the ducts followed by pancreatectomy causes an immediate disappearance of the high values of the enzyme in the urine. From these findings we concluded that the fat-splitting enzyme in the urine is identical with the pancreatic lipase.

Lipase has also been detected regularly in the . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Medical and Surgical Departments of the New England Center Hospital and Tufts University Medical School.

Footnotes
Submitted for publication Nov. 21, 1957.

Supported by a grant from the Damon Runyon Memorial Fund for Cancer Research.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?