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Plasma Thromboplastin Antecedent (PTA) Deficiency
EDMUND W. CAMPBELL, M.D.;
IRMA B. MEDNICOFF;
WILLIAM DAMESHEK, M.D.
AMA Arch Intern Med. 1957;100(2):232-240.
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Plasma thromboplastin antecedent (PTA) deficiency was first described by R. L. Rosenthal et al., in 1953,1 as a mild to moderately severe hereditary hemorrhagic disease resembling hemophilia but occurring in both males and females. Further studies by the same group revealed fairly well-defined distinctions between antihemophilic globulin (AHG), plasma thromboplastin component (PTC), and PTA.2 Only a few subsequent cases of PTA deficiency have been reported.3,4 The present report deals with a family in which a coagulation disorder, eventually diagnosed as PTA deficiency, was found.* Both males and females were affected, inheritance taking place either through males or females. Of the 10 members of the family available for study, 5 showed indications of the disease (Fig. 1). However, the variability in laboratory tests indicated a somewhat less well-defined character of the deficient factor than is found in either the AHG or the PTC coagulation defect. In the case
. . . [Full Text PDF of this Article]
Author Affiliations
Boston
From the Blood Research Laboratory, a unit of the Ziskind Laboratories, New England Center Hospital, and the Department of Medicine, Tufts University Medical School.
Footnotes
Submitted for publication Feb. 21, 1957.
This work was supported by U. S. P. H. S. National Heart Institute Grant No. H-2636.
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