The Serology of Autoimmune Hemolytic DiseaseObservations on Forty-One Patients
ROBERT S. EVANS, M.D.;
RUSSELL S. WEISER, M.D.
AMA Arch Intern Med. 1957;100(3):371-399.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
Introduction During the past 10 years new and improved serological techniques have permitted the demonstration and characterization of the antibodies of acquired hemolytic anemia even though little is known about their genesis. The antibodies of this disease syndrome resemble the isoantibodies evoked by incompatible transfusions and maternal-fetal incompatibility in many characteristics of serological behavior except for their unique property of autoactivity. Prior to the last decade serological demonstration of antibodies in acquired hemolytic anemia was possible only in unusual instances in which hemolysis occurred in vitro, since agglutination of red cells in saline media by these abnormal proteins is rarely if ever observed. When cold agglutinins were present in association with acquired hemolytic anemia, agglutination of the patients' red cells was frequently noted. However there was little evidence that these antibodies were the cause of the persistent abnormal destruction, since they were frequently present without causing hemolytic anemia and appeared
. . . [Full Text PDF of this Article]
Author Affiliations
Seattle
Medical Service of the Veterans' Administration Hospital and the Departments of Medicine and Microbiology, University of Washington School of Medicine.
Footnotes
Submitted for publication April 1, 1957.
Supported by a grant in aid from the United States Public Health Service.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati
What's this?
|
