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ALEXANDER P. REMENCHIK, M.D.; JOHN A. MOORHOUSE, M.D.

AMA Arch Intern Med. 1957;100(3):445-452.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Modern textbooks of cardiology ^1,2 ascribe a major role to an increase in blood volume to explain the pathogenesis of the signs and symptoms of congestive cardiac failure. This concept has been challenged by the observations of Prentice et al.³ and of Ross and his co-workers,^4,5 who used P³²-labeled erythrocytes instead of Evans blue dye to measure the blood volume in patients with congestive cardiac failure and in dogs in which congestive cardiac failure had been produced by experimental means.

Part of the difficulty may lie in the use of the ambiguous phrase "blood volume." The term "blood volume" is employed to designate the anatomical compartment bounded by the endothelial cells of the vascular system, i. e., the actual physical space enclosed within the heart and the arterial, capillary, and venous vessels. We have chosen the term "intravascular volume" to denote this physical space. The methods . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Department of Medicine, University of Illinois College of Medicine; Instructor in Medicine (Dr. Remenchik) and Research Fellow (Dr. Moorhouse).

Footnotes
Submitted for publication March 6, 1957.

Supported in part by a grant (H-1029) from the United States Public Health Service.

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