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The Correction of Plasma Thromboplastin Antecedent Deficiency

RUBEN LISKER, M.D.; AARON M. JOSEPHSON, M.D.; GEORGE WERBIN, M.D.; CHARLES M. SHAPIRO, M.D.; SIMON ROZENGVAIG, M.D.

AMA Arch Intern Med. 1957;100(3):474-477.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The preoperative preparation of patients manifesting a systemic hemorrhagic diathesis has always presented the physician with a serious and often difficult problem. Very few reports dealing with the correction of the coagulation defect of plasma thromboplastin antecedent (PTA) deficiency are to be found in the literature. Rosenthal et al. have been able to correct the PTA deficiency of some patients with a single transfusion of 500 cc. of seven-day-old plasma.¹,² The correction, as measured by in vitro techniques, persisted for seven days in one patient. Another patient was normalized for 24 hours after infusion of only 50 cc. of plasma.³

The patient reported in this article required transfusions of large amounts of blood for correction of the in vitro test. This patient was previously reported from this department as a well-documented case of PTA deficiency.⁴

Methods

The routine hematologic tests were performed with the usual methods. . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

Footnotes
Submitted for publication March 12, 1957.

Drs. R. Ginsberg, H. Sapoznik, M. Parker, and R. Shapiro gave permission for use of this patient in our studies.

From the Department of Hematologic Research, Medical Research Institute, the Department of Medicine, and the Department of Surgery, Michael Reese Hospital. The Department of Hematologic Research is in part supported by the Michael Reese Research Foundation and by the Hulda B. and Maurice L. Rothschild Foundation for Scientific Research. Ruth Reader Berger Fellow, Hematology Research Foundation 1955/1956 (Dr. Rozengvaig).

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