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II. Prophylaxis with Tandem Oral Penicillin

CAPT. HAROLD P. LAZAR, MC; CAPT. GERALD I. MAAS, MC; CAPT. WALTER HARRISON, MSC; COL. JAMES H. HAMMOND, MC; LOWELL A. RANTZ, M.D.

AMA Arch Intern Med. 1957;100(4):614-619.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The efficacy of penicillin in the prevention of streptococcal infections and rheumatic fever is a well-documented fact.^1-4 Exposure of large numbers of service recruits to virulent streptococci has been followed by massive outbreaks of epidemic acute rheu- matic fever with its attendant serious cardiac sequelae.5 A previous report recounted the epidemiology and clinical picture of epidemic acute rheumatic fever as it was experienced in the first half of 1955 at a large Air Force basic training center in Northern California.6 It is the purpose of this paper to relate and discuss an approach to the practical aspects of streptococcal disease and rheumatic fever prevention, with particular reference to a tandem oral penicillin method of prophylaxis.

Background

While rheumatic fever attack rates are notoriously inaccurate, Northern California has never been noted as a particularly vulnerable area. When, however, 58 well-documented cases of acute rheumatic fever were accumulated in . . . [Full Text PDF of this Article]

Author Affiliations
U.S.A.F., Parks Air Force Base, Calif.; San Francisco

Footnotes
Submitted for publication Feb. 11, 1957.

From the Department of Medicine and the Streptococcal Disease Control Board, 3275th U. S. A. F. Hospital, Parks Air Force Base, Calif., and the Department of Medicine, Stanford University School of Medicine, San Francisco. Aided by Grant No. H 700 from the National Heart Institute, National Institutes of Health.

Streptococcal Disease Control Coordinator; now at Michael Reese Hospital, Chicago; present address, 3550 Pine Grove Ave., Chicago 13, (Capt. Lazar). Member, Streptococcal Disease Control Board, (Capt. Maas). Administrative Sanitary Officer (Capt. Harrison). Chief, Department of Medicine, and Streptococcal Disease Control Officer (Col. Hammond). Professor of Medicine, Stanford University School of Medicine, and Consultant, 3275th U. S. A. F. Hospital, Parks Air Force Base, Calif. (Dr. Rantz).

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