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A Clinical, Metabolic, and Hormonal Study

HERTA SPENCER, M.D.; ISAAC LEWIN, M.D.; DANIEL LASZLO, M.D.; ROY HERTZ, M.D.; ATTALLAH KAPPAS, M.D.; THOMAS F. GALLAGHER, Ph.D.

AMA Arch Intern Med. 1957;100(4):658-668.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The cooperative effort of three groups of investigators made it possible to study the clinical course and the metabolic and hormonal derangement of a patient with adrenal carcinoma and the responsiveness of the tumor to hormone stimulation and Amphenone (1,2-bis[p-aminophenyl]-2-methylpropanone-1-dihydrochloride) t h e r a p y.^1-5 This study covers a period of four years during which three stages of the course of Cushing's syndrome were investigated. The first stage illustrates the presence of significant hormonal and metabolic aberrations, although there was a paucity of clinical signs and symptoms. The second stage, which followed the removal of an adrenal tumor, illustrates the reversibility of Cushing's syndrome in both clinical and biochemical parameters. This remission, considered to be a "cure," lasted, however, only approximately three and one-half years. It was interrupted by the sudden emergence of pronounced virilization associated with significant hormonal and metabolic aberrations. This third stage . . . [Full Text PDF of this Article]

Author Affiliations
New York; Bethesda, Md.; New York

Montefiore Hospital (Drs. Spencer, Lewin, and Laszlo), National Cancer Institute (Dr. Hertz), and Sloan-Kettering Institute for Cancer Research (Drs. Kappas and Gallagher).

Footnotes
Submitted for publication March 21, 1957.

This study was supported by grants from the National Cancer Institute ([C-1540] and [C-322]), National Institute of Arthritis and Metabolic Diseases (A-855), United States Public Health Service, and the American Cancer Society.

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