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With Observations on the Use of Methionine as a Urinary Antiseptic

EDWARD H. KASS, M.D., Ph.D.

AMA Arch Intern Med. 1957;100(5):709-714.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Pyelonephritis and related infections of the urinary tract are among the most frequently encountered, most frequently undiagnosed, and most difficult to manage of all infections. The lack of clear views of the pathogenesis, diagnosis, and treatment of infections of the urinary tract is well recognized.^1-3

A few selected data indicate the magnitude of the problem.

1. Pyelonephritis is the commonest disease of the kidneys at autopsy. Active pyelonephritis has been found in 10% to 20% of autopsies in several general hospitals,^4-6 and healed pyelonephritis occurs about as frequently as does active pyelonephritis.⁶

2. Pyelonephritis has been implicated, with varying degrees of evidence, in such disorders as hypertension, chronic renal insufficiency, toxemias of pregnancy, various disturbances in electrolyte metabolism, diabetes mellitus, pregnancy, and stone formation.

3. Despite the importance of this group of diseases the diagnosis of infection of the urinary tract is made in only about 20% . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Thorndike Memorial Laboratory, Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School.

Footnotes
Submitted for publication June 4, 1957.

Aided by grants from the National Institutes of Health, United States Public Health Service.

Read in the Symposium on Urinary Tract Infection before the Section on Experimental Medicine and Therapeutics at the 106th Annual Meeting of the American Medical Association, New York, June 4, 1957.

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