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OLOF H. PEARSON, M.D.

AMA Arch Intern Med. 1957;100(5):724-728.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The increased growth of the body as a whole at the time of sexual maturation early suggested a causal interrelationship of these two phenomena. This was further emphasized by the development of precocious puberty in association with gonadal tumors. In this situation a rapid increase in body weight and height, maturation of the musculature and skeleton, deepening of the voice, and growth of sexual hair may be observed together with precocious development of the genitalia.

When the gonadal steroids became available for study in man, Kenyon and his co-workers ¹ demonstrated that testosterone propionate exerts anabolic effects on tissues other than those of the genital system. Thus a person eating a constant diet may gain as much as 9 kg. in body weight during testosterone administration, which is more than can be accounted for by growth of the genitals. Metabolic balance studies have shown that under the influence of androgenic . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Division of Clinical Investigation, Sloan-Kettering Institute and the Medical Service, Memorial and James Ewing Hospitals, Memorial Center.

Footnotes
Submitted for publication July 3, 1957.

These studies were supported in part by grants from the National Cancer Institute, National Institute of Health, United States Public Health Service, the United States Atomic Energy Commission, and the American Cancer Society, Inc. Read in the Symposium on the Use of Androgens and Estrogens and Their Metabolic Effects before the Joint Meeting of the Section on Experimental Medicine and Therapeutics and the Section on Internal Medicine at the 106th Annual Meeting of the American Medical Association, New York, June 6, 1957.

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