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ROBERT M. BLIZZARD, M.D.; LAWSON WILKINS, M.D.

AMA Arch Intern Med. 1957;100(5):729-738.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since 1950, when cortisone was first used for the treatment of virilizing adrenal hyperplasia, the methods and results of therapy have been reported from time to time from this clinic ^1-9 and by other workers,^10-13 and the differential diagnosis also has been discussed.⁸,⁹ This paper summarizes briefly the present concepts concerning the pathogenesis and differential diagnosis of this disorder, and the results of treatment with cortisone and some of the newer closely related steroids.

As shown in Table 1, of 87 patients observed 68, or 78%, were female pseudohermaphrodites. It is probable that this does not represent the true sex distribution, as the diagnosis is made more readily in females, while males often die in infancy from salt loss before the true nature of the disorder is suspected. Thirty, or approximately one-third, of the patients had associated salt-losing symptomatology. Seventy-five patients have been treated, of whom only . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore, Md.

From the Department of Pediatrics, The Johns Hopkins University School of Medicine and the Harriet Lane Home, The Johns Hopkins Hospital. Formerly Fellow of the National Foundation for Infantile Paralysis (Dr. Blizzard). Present address of Dr. Blizzard: Assistant Professor of Pediatrics and Assistant Professor of Medicine, Ohio State University Medical Center, Children's Hospital, Columbus, Ohio.

Footnotes
Submitted for publication June 26, 1957.

Read in the Symposium on the Use of Androgens and Estrogens and Their Metabolic Effects before the Joint Meeting of the Section on Experimental Medicine and Therapeutics and the Section on Internal Medicine at the 106th Annual Meeting of the American Medical Association, New York, June 6, 1957.

This work was made possible by a Grant-in-Aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council and by a research grant from the Division of Research Grants and Fellowships of the National Institutes of Health, United States Public Health Service.

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