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The Effects of Estrogens on Serum Lipids in Women
ROGER W. ROBINSON, M.D.;
NORIO HIGANO, M.D.;
WILLIAM D. COHEN, Ph.D.
AMA Arch Intern Med. 1957;100(5):739-743.
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In 1949 Eilert demonstrated the lipid-shifting effects of estrogens in postmenopausal and castrated women.1 Because of the preponderance of men suffering from coronary heart disease in middle age the relationship between the lipid effects of estrogens and coronary atherosclerosis has been studied chiefly in men. Recently several groups have clearly documented the striking effects of estrogens on the serum lipids of men with coronary heart disease when employed in adequate dosage for sufficient time.2-6 However, since there is an increased incidence of coronary heart disease in postmenopausal women, the growth of the aging population has resulted in an increasingly important number of women suffering from this disease.
The rise of serum cholesterol levels in women with advancing age has been well established,7-9 but the reasons for this remain obscure. The physiological decrease of ovarian function as reflected by the progressive fall of urinary estrogen levels in aging
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Author Affiliations
Worcester, Mass.
From the Medical Division and the Research Laboratory of The Memorial Hospital.
Footnotes
Submitted for publication June 6, 1957.
This investigation was supported by grants from the United States Public Health Service (Nos. H-1932 and H-2658), The Worcester District Chapter of the Massachusetts Heart Association, and The William B. and Isabel H. Smith Fund.
Read in the Symposium on the Use of Androgens and Estrogens and Their Metabolic Effects before the Joint Meeting of the Section on Experimental Medicine and Therapeutics and the Section on Internal Medicine at the 106th Annual Meeting of the American Medical Association, New York, June 6, 1957.
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