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Experimental Basis for Anabolic Therapy
GILBERT S. GORDAN, M.D., Ph.D.
AMA Arch Intern Med. 1957;100(5):744-749.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Currently, chemical analogs of the naturally occurring hormones are being prepared and studied in large quantities in the hope of finding useful therapeutic agents. The recent demonstration that naturally occurring hormones that were once thought to be single are really complexes of metabolically active substances has multiplied the number of known hormones remarkably. For example, in the case of the thyroid hormones we now know that thyroxin is but one of a large complex of chemically related substances and that some of its metabolites are, in fact, more potent than thyroxin itself. There is also some indication that the degradation products may be different, not only quantitatively but also qualitatively, in their metabolic actions. For example, triiodothyropropionic acid, which may be looked upon as a deiodinated, deaminated analogue of thyroxin, has only 15% of the ability of l-thyroxin to increase oxygen consumption and only one-quarter of its ability to
. . . [Full Text PDF of this Article]
Author Affiliations
San Francisco
From the Endocrine Clinic of the Department of Medicine, University of California School of Medicine, and The Langley Porter Clinic of the State Department of Mental Hygiene.
Footnotes
Submitted for publication June 6, 1957.
Read in the Symposium on the Use of Androgens and Estrogens and Their Metabolic Effects before the Joint Meeting of the Section on Experimental Medicine and Therapeutics and the Section on Internal Medicine at the 106th Annual Meeting of the American Medical Association, New York, June 6, 1957.
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