 |
|
Treatment of Acute Gouty Arthritis with Demecolcine
JACOB COLSKY, M.D.;
STANLEY WALLACE, M.D.;
MORRIS M. BANOWITCH, M.D.
AMA Arch Intern Med. 1957;100(5):765-773.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
Demecolcine (desacetylmethylcolchicine) is one of a number of alkaloids which have been isolated from the plant Colchicum autumnale, which is also the source of colchicine. The chemical structure of demecolcine differs from colchicine only in that a methyl group replaces the acetyl group at the N position of the colchicine molecule (Fig. 1).1,2
Numerous studies of the pharmacological effects of this drug in animals have been reported.1,3-5 It has been used in doses of 3 to 20 mg. daily for the treatment of patients with chronic myelogenous leukemia and other neoplastic diseases. Gastrointestinal disturbances, so commonly seen following the ingestion of much smaller doses of colchicine, have not been noted.3,4,6 Skin rash, depilation, and bone marrow depression, manifested by leukopenia, thrombopenia, and anemia, have occurred in some of these patients.3,4
Because of the chemical similarity of demecolcine and colchicine, we decided to observe its effect in
. . . [Full Text PDF of this Article]
Author Affiliations
Brooklyn
From the Medical Services, Maimonides Hospital of Brooklyn, and the Department of Medicine, State University of New York College of Medicine at New York City. Present address University of Miami, School of Medicine, Miami, Fla. (Dr. Colsky).
Footnotes
Submitted for publication March 26, 1957.
The Ciba Pharmaceutical Products, Inc., Summit, N. J., supplied the demecolcine (Colcemid) used in this study.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
