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AMOS H. LIEBERMAN, M.D.; JOHN A. LUETSCHER, Jr., M.D.

AMA Arch Intern Med. 1957;100(5):774-779.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Aldosterone is the most active corticosteroid secreted by the adrenal cortex in promoting sodium retention and elimination of potassium. In physiological amounts it is believed that aldosterone predominates in the control of sodium and potassium balance, while carbohydrate metabolism and various other functions are affected by hydrocortisone.

Secretion of aldosterone and secretion of hydrocortisone by the human adrenal cortex appear to be regulated by distinctly different mechanisms.

According to present concepts (Fig. 1) a neurohumoral substance secreted by the hy

Hypothalamus Anterior Pituitary Adrenal Cortex Circulating Hydrocortisone Hypothalamus Diencephalon Anterior Pituitary Adrenal Cortex Aldosterone t Na Reabsorption K Reabsorption? Extrarenal Effects Extracellular Fluid Volume (? Blood Volume)

Fig. 1.

—Regulatory mechanisms for control of hydrocortisone and aldosterone secretion. Present concepts of regulation derived from available evidence. Broken arrows are used when supporting evidence is only suggestive. pothalamus acts upon the anterior pituitary gland to release adrenocorticotropin, which stimulates the adrenal cortex . . . [Full Text PDF of this Article]

Author Affiliations
San Francisco

From the Department of Medicine, Stanford University School of Medicine.; Trainee of the National Institute of Arthritis and Metabolic Diseases, Public Health Service (Dr. Lieberman).

Footnotes
Submitted for publication June 3, 1957.

Miss Anne Dowdy, Miss Julia Harvey, Mr. Way Lew, and Mr. Lee J. Poo assisted in this study.

This work was supported by a grant-in-aid from the National Institute of Arthritis and Metabolic Diseases, Public Health Service.

Read before the Section on Internal Medicine at the 106th Annual Meeting of the American Medical Association, New York, June 6, 1957.

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