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LEO WAYNE, M.D.; JOHN J. WILL, M.D.; BEN I. FRIEDMAN, M.D.; LOUIS S. BECKER, M.D.; RICHARD W. VILTER, M.D.

AMA Arch Intern Med. 1958;101(1):143-155.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Vitamin B₆ is required as a growth factor by a wide variety of bacteria, yeasts, and molds and for the nutrition of all species of animals studied. In man it is an essential nutrient, and deficiency of vitamin B₆ results in characteristic alterations of the skin, mucous membranes, and nervous system. Like other vitamins, vitamin B₆ functions as a coenzyme of importance in a wide variety of enzyme systems concerned with intermediary metabolism.

Vitamin B₆ is now used as a class name to include all compounds having vitamin B₆ activity. These include pyridoxine, pyridoxal, and pyridoxamine. To Gyorgy¹ (1934) goes the credit for establishing vitamin B₆ as an entity in the vitamin B complex. Within two years of the original observations of Gyorgy, five independent reports announced the isolation of pyridoxine from various natural materials.^2-6 In 1939, Harris and Folkers⁷ successfully synthesized pyridoxine. Snell⁸ recognized the existence of other . . . [Full Text PDF of this Article]

Author Affiliations
Cincinnati

From the Department of Internal Medicine, University of Cincinnati College of Medicine and the Cincinnati General Hospital.

Footnotes
Submitted for publication July 12, 1957.

Read before the Section on Internal Medicine at the 106th Annual Meeting of the American Medical Association, New York, June 5, 1957.

Observations reported for the first time in this paper were made under grants from the National Vitamin Foundation, New York, and from Merck & Co., Inc., Rahway, N. J.

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