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Observations on Quinine and Acetophenetidin (Phenacetin)

E. E. MUIRHEAD, M.D.; E. R. HALDEN, M.D.; M. GROVES, M.T. (ASCP)

AMA Arch Intern Med. 1958;101(1):87-96.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The Coombs (antiglobulin) test as applied to erythrocytes has been especially of value in the identification and study of isoimmune states^1,2 and in acquired hemolytic anemia^3,4 in which an autoimmune state has been proposed.^5,6 Recently Harris⁷ described an additional application of the Coombs test to erythrocytes which was dependent on humoral factors in the patient's serum plus the trivalent antimony compound stibophen (Fuadin). This phenomenon, associated with a hemolytic state due to multiple contacts by the patient with the drug stibophen, may be compared with the drug-dependent agglutination of platelets described by Ackroyd ^8,9 in the thrombocytopenia induced by allylisopropylacetylcarbamide (Sedormid) and varified for quinidine ^10-12 and quinine.¹³ It is also of interest that the agglutination of leukocytes dependent on serum factors and a drug, similar to Ackroyd's phenomenon for platelets, has been described.¹⁴

In the present report we wish to record the encounter of a positive Coombs test for . . . [Full Text PDF of this Article]

Author Affiliations
Dallas, Texas

From the Departments of Pathology and Medicine, The University of Texas Southwestern Medical School.

Footnotes
Submitted for publication July 29, 1957.

Supported by a grant from the National Heart Institute, United States Public Health Service.

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