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I. The Common Cold as a Clinical Entity

GEORGE GEE JACKSON, M.D.; HARRY F. DOWLING, M.D.; IRWIN G. SPIESMAN, M.D.; ARTHUR V. BOAND, Ph.D.

AMA Arch Intern Med. 1958;101(2):267-278.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The common cold is one of the most frequent and universal infections of man. Nevertheless, little is known regarding its specific etiology, and the diagnosis must be a clinical one. Until the infectious agent can be propagated, characterized by microbiologic and pathologic methods and consistently transmitted to experimental animals or in tissue cultures, transmission to humans appears to be the best method for study. In this manner, information can be obtained about the nature of the infection, factors that influence the susceptibility or resistance of the human host, and conditions that favor spread of the illness.

During the past five years we have made observations upon more than 1000 volunteers who were challenged with infectious nasal secretions obtained from persons with a common cold or with a blank solution used as a control. The clinical findings were re- corded daily. Examination of the nose and throat was of no value . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Departments of Medicine and Otolaryngology, University of Illinois College of Medicine.

Footnotes
Submitted for publication Sept. 30, 1957.

The following persons made contributions in these experiments: Hans G. Grieble, M.D.; Truman O. Anderson, Ph.D.; Tohru Inouye, M.S.; Frieda K. Webb; Delores H. Seketa; Betty R. Connor, M.S.; Louise R. Jensen; Marvin Turck; Theodore Wakefield, M.D., and Raymond Maurer, M.D.

These studies were carried out under the sponsorship of the Commission on Acute Respiratory Diseases, Armed Forces Epidemiology Board, and were supported in part by the Office of the Surgeon General, Department of the Army, and in part by grants from the Lederle Laboratories Division, American Cyanamid Company, and Charles Pfizer & Company, Inc.

Dr. Spiesman died Sept. 11, 1954.

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