This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (43)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

SIDNEY H. INGBAR, M.D.; NORBERT FREINKEL, M.D.

AMA Arch Intern Med. 1958;101(2):339-346.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recent advances have provided a great variety of techniques designed to assess the normal and disordered physiology of the thyroid gland. By and large, these procedures supplement rather than replace one another, and, when employed together, they make possible an integrated analysis of diverse aspects of thyroidal function and the metabolism of iodine. Thus, it is possible to assess the avidity of the thyroid gland for iodine, the quantity of thyroid hormone produced, its rate of release from the gland, the rate of peripheral degradation of hormone, and the concentration and chemical nature of hormonal iodine in the blood.^1,2

Subacute, giant cell, or de Quervain's thyroiditis is a disease which is puzzling both in its etiology and in its pathologic physiology. In this disease, commonly employed measures of thyroidal function frequently display a seemingly paradoxical divergence from normality. For example, although the thyroidal uptake of radioiodine is characteristically diminished, . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Department of Biophysics, Army Medical Service Graduate School, Walter Reed Army Medical Center, Washington, D. C.; the Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services, Boston City Hospital; the Department of Medicine, Harvard Medical School, Boston, and the Howard Hughes Medical Institute. Formerly Captain (MC), U. S. Army; at present, Investigator, Howard Hughes Medical Institute (Drs. Ingbar and Freinkel).

Footnotes
Submitted for publication Sept. 30, 1957.

This investigation was supported in part by Research Grant A-627 from the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, and in part by the Medical Research and Development Board, Office of the Surgeon General, Department of the Army, under Contract No. DA-49-007-MD-412.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?