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ALLAN J. ERSLEV, M.D.

AMA Arch Intern Med. 1958;101(2):407-417.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

A moderate or often severe anemia of the normochromic normocytic type is usually present in patients with chronic renal disease. In 1950, Callen and Limarzi¹ made a careful hematologic study of 102 patients with renal disorders and reviewed the literature pertinent to this anemia. They concluded (1) that there was a functional suppression of the normoblastic elements of the bone marrow in renal disease with uremia and (2) that the degree of anemia appeared to be roughly proportional to the impairment in kidney function as measured by the level of nonprotein nitrogen in serum. Kidney pathology per se without retention of nitrogenous products in the blood was not associated with anemia. Recent studies of nephrectomized animals,^2-3 as well as studies of patients with uremia in whom the turnover of radioactive iron was measured,^4-6 have supported these conclusions.

Such studies have shown, in addition, that the anemia . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services, Boston City Hospital, and the Department of Medicine, Harvard Medical School.

Footnotes
Submitted for publication Sept. 30, 1957.

Miss Elva Ruiz assisted in this investigation.

This investigation was supported by Research Grant No. A-795 (C) from the National Institutes of Health, Public Health Service.

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