This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

ARTHUR L. DUNN, Ph.D.; JOHN R. WALSH, M.D.; JOSEPH M. HOLTHAUS, M.D.

AMA Arch Intern Med. 1958;101(5):927-931.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since 1952, Co⁶⁰ cyanocobalamin (vitamin B₁₂) has been used to confirm the diagnosis of pernicious anemia. Its main advantage is that it is an effective diagnostic agent whether or not cyanocobalamin or liver extract has been taken as a form of treatment. It is in this particular group of patients who have been given treatment and in whom the ordinary diagnostic laboratory tests have been obscured by the effects of the therapy that this test is particularly useful.

Four methods for measuring the absorption of orally administered radioactive cyanocobalamin are currently used. After the oral administration of Co⁶⁰ cyanocobalamin, measurement of radioactivity in the stool,¹ hepatic uptake of Co⁶⁰ cyanocobalamin,^2,3 and recovery of the radioactive cyanocobalamin in the urine⁴ have all been used. Recently Co⁵⁶ cyanocobalamin has been measured in the plasma after oral administration.⁵ Schilling's method of measuring Co⁶⁰ cyanocobalamin in a 24-hour urine sample has been widely adopted . . . [Full Text PDF of this Article]

Author Affiliations
Omaha

From the Radioisotope Service and Medical Service, Veterans' Administration Hospital.

Footnotes
Submitted for publication Aug. 5, 1957.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?