This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Clinical Pathological Study

MOSHE B. GOLDGRABER, M.D.; JOSEPH B. KIRSNER, M.D.; HOWARD F. RASKIN, M.D.

AMA Arch Intern Med. 1958;102(1):10-24.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Chronic granulomatous inflammation¹ is a process initiated usually by a group of harmful agents which bring into defensive activity a specialized cellular mechanism-the reticuloendothelial system. The basic lesion, a granuloma in typical cases, contains at the periphery concentric reticular fibers, while the center is occupied by epithelioid cells, with or without giant cells. Such granulomata have been found in a variety of infections, such as tuberculosis,² syphilis,³ and cat-scratch fever.⁴ Similar granulomata have been noted in sarcoidosis,^5,6 in chronic ulcerative colitis, and in regional enteritis, diseases currently considered nonspecific, in view of lack of knowledge of their etiology. Granulomata are found in berylliosis,⁷ in silicosis,⁸ and in other conditions when foreign bodies have some into intimate contact with living tissue. Granulomata have been observed also as part of a local tissue response in hypersensitivity reactions produced in the experimental animal with specific . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

Department of Medicine, The University of Chicago.

Footnotes
Submitted for publication Nov. 15, 1957.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?