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A Critical Review

MOSHE B. GOLDGRABER, M.D.; JOSEPH B. KIRSNER, M.D., Ph.D.

AMA Arch Intern Med. 1958;102(1):134-148.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

There is an increasing awareness of the potential role of immunologic disorders in human disease. Recent reports^1-6 suggest a hypersensitivity mechanism in diseases such as Hashimoto's disease ¹ chronic thyroiditis,³ and acute hemorrhagic pancreatitis,³ acute hepatitis,⁴ certain instances of acute ulcerative colitis,⁵ acute glomerulonephritis and the nephrotic syndrome,⁶ sarcoidosis,⁷ and Whipple's disease.^8,9 Whereas symptoms caused by allergic reactions were attributed originally to change in function only,¹⁰ subsequent studies have indicated conspicuous alterations in tissues, the site of a local hyperimmune state. Widespread pathological changes can be found also in the acute generalized anaphylactic reactions.^11-13 Gastrointestinal hypersensitivity is rarely diagnosed clinically, however, chiefly because of the difficulty in demonstrating an antigen-antibody relationship in any given case. During recent studies on human stomach and colon tissue^14,15 and in the experimental animals¹⁶ information was collected regarding hypersensitivity reactions in the gastrointestinal tract. It seemed of interest to review this material as an . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

Department of Medicine, The University of Chicago.

Footnotes
Submitted for publication Feb. 15, 1958.

This study was supported in part by a grant from the National Institutes of Health, (National Institute of Arthritis and Metabolic Diseases).

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