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LEO P. KRALL, M.D.; RAFAEL CAMERINI-DAVALOS, M.D.

AMA Arch Intern Med. 1958;102(1):25-31.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The current medical literature contains many reports of studies with oral hypoglycemic agents.^1-3 These substances thus far have been sulfonylurea derivatives with blood-sugar-lowering ability in certain types of diabetes. Within the last year studies were started with a new group of compounds classified as formamidinyliminoureas. These drugs are biguanides, not to be confused with the diguanidines, which include Synthalin (guanidine-deca-methylene-guanidine) (Fig. 1). They also have no structural relationship to either carbutamide or tolbutamide and have no sulfonyl radical in their formulae. Ungar et al.⁴ recently reported that one of these agents, phenethylformamidinyliminourea hydrochloride, was effective orally in both normal and alloxandiabetic animals. He also reported⁵ the uptake of glucose by a rat diaphragm preparation. Williams⁶ reported a hypoglycemic effect in animals, and Nielsen et al.⁷ stated that this hypoglycemic effect was observed in depancreatized animals. Pomeranze⁸ first demonstrated successful hypoglycemic effects in clinical trials with patients.

This present report is . . . [Full Text PDF of this Article]

Author Affiliations
Boston

The Arlington-Funk Division, U. S. Vitamin Corporation, New York, furnished materials and assistance for this study.

Footnotes
Submitted for publication Dec. 7, 1957.

Physician, Joslin Clinic and New England Deaconess Hospital, Boston (Dr. Krall).

Presented in part at the 17th annual meeting of American Diabetes Association in New York City, June, 1957.

Research Fellow, Baker Clinic Research Laboratory, New England Deaconess Hospital, Boston, and Assistant Clinical Professor of Medicine, University of Buenos Aires (Dr. Camerini-Davalos).

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