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Metabolism, Biochemistry, and Clinical Pathological Physiology— Review of Recent Literature

ROLAND DEMULDER, M.D.

AMA Arch Intern Med. 1958;102(2):254-301.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In general biology, iron plays an irreplaceable role as a catalyzer. It is found in every living species, but its proportion increases as evolution progresses in the animal kingdom.

The oligoelement has many virtues, one of them being a growth-promoting capacity. A culture of beer yeast in an iron-free medium presents only a poor development; the same phenomenon is observed on many other organisms.

The biocatalyzing property has been known since Warburg demonstrated the transportation of oxygen by the metal. Iron is found in cellular ferments, where it edifies ferric porphyrins, the most famous example of which is hemoglobin. Within these enzymes it keeps its variable valency Fe⁺⁺ and Fe⁺⁺⁺ that enables it to transfer ions and to participate in oxidoreduction processes; thus iron bestows their activity to the cytochromes, peroxidases, catalase, and cytochrome oxidase, Warburg's yellow ferment. Cellular life would be impossible without iron.

The erythropoietic property will be . . . [Full Text PDF of this Article]

Author Affiliations
Brussels, Belgium

From the Hospital Department of Internal Medicine; Head, Dr. Jacques Dagnelie, 1952-1955.

Footnotes
Submitted for publication Jan. 8, 1958.

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