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WILLIAM D. ODELL, M.D.; DONALD C. TANNER, M.D.; DONALD F. STEINER, M.D.; ROBERT H. WILLIAMS, M.D.

AMA Arch Intern Med. 1958;102(4):520-526.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1926, Frank et al.¹ synthesized Synthalin A (decamethylenediguanidine) and showed that oral administration of the drug lowered the blood sugar remarkably in partially depancreatized animals and in human diabetics. A few diabetic patients were treated with Snythalin A, but it was subsequently proved to be quite toxic even in small doses,^2,3 producing histological changes in the liver and kidney after one or two days, and all clinical use of the drug was discontinued. However, other compounds containing this guanidine group (Fig. 1) were not so toxic. Indeed, it is known that normal body constituents such as creatine and arginine contain the guanidine group. Also, Paludrine [N₁-(p-chlorophenyl)-N₅-isopropylbiguanide] has a mild hypoglycemic action, and it has been used successfully for several years in the treatment of malaria.^12,13

Recently, in a search for hypoglycemic compounds, Ungar⁴ found that phenethylformamidinyliminourea (also referred to as phenethyldiguanide, or DBI, but preferably called phenethylbiguanide, or PEBG) . . . [Full Text PDF of this Article]

Author Affiliations
Seattle

Department of Medicine, University of Washington School of Medicine.

Footnotes
Submitted for publication June 3, 1958.

Dr. Emily Fergus cooperated in and referred patients for use in this study.

All biguanide compounds used were supplied by the U. S. Vitamin Corporation.

This investigation was supported in large part by research grants from the National Institute of Arthritis and Metabolic Diseases, Public Health Service.

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