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Surfeit and Deficit of SodiumA Kinetic Concept of Sodium Excretion
MAURICE B. STRAUSS, M.D.;
EZRA LAMDIN, M.D.;
W. PIERCE SMITH, M.D.;
DANIEL J. BLEIFER, M.D.
AMA Arch Intern Med. 1958;102(4):527-536.
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Normal man can maintain an over-all sodium balance at intakes varying from a few to 1000 mEq. or more of sodium daily. Although this balance is customarily referred to as a steady state, at all levels of sodium intake higher than a few milliequivalents daily it represents in reality a constantly fluctuating level of total body sodium. Each time sodium is ingested a positive balance is produced which is steadily reduced in the following hours by way of renal sodium excretion. This is well illustrated in a study from this laboratory1 in which identical meals and quantities of salt were administered to constantly recumbent subjects at six-hour intervals. Figure 1, plotted for the second day of this study, reveals that the sodium ingested at the beginning of each six-hour period has just about been eliminated by the end of the period, save for the night hours, particularly from midnight
. . . [Full Text PDF of this Article]
Author Affiliations
Boston
From the Medical Service and Research Laboratory, Boston Veterans' Administration Hospital and the Departments of Medicine, Boston University and Tufts University Schools of Medicine.
Footnotes
Submitted for publication May 21, 1958.
Presented at the Stanford University School of Medicine, San Francisco, May 15, 1958.
Read by title at the 71st Annual Meeting of The Association of American Physicians, Atlantic City, N. J., May 7, 1958.
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