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HANS SELYE, M.D.; IGNACIO de SALCEDO, M.D.

AMA Arch Intern Med. 1958;102(4):551-557.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It has long been known that many actions of hormones are not direct but are due to the creation of favorable conditions for the actions of nonhormonal agents.¹ In our institute this phenomenon of "conditioning" by hormones of the sensitivity to nonendocrine stimuli has been studied, particularly in relation to the actions of electrolytes. It was found, for example, that the production of nephrosclerosis, myocarditis, and periarteritis nodosa by deoxycorticosterone does not depend upon the direct effects of the hormone but upon its ability to sensitize tissues to dietary sodium chloride.^2,3 Apparently, it is through an essentially similar mechanism that deoxycorticosterone produces favorable conditions for the production of nephrocalcinosis, by the concurrent administration of, in themselves, inactive doses of phosphate.⁴

A particularly striking instance of the selective conditioning of cardiac tissue for the toxic actions of dietary sodium phosphates (NaH₂PO₄ and Na₂HPO has recently come to our attention. Rats treated . . . [Full Text PDF of this Article]

Author Affiliations
Montreal

Institut de médecine et de chirurgie expérimentales, Université de Montréal.

Footnotes
Submitted for publication Jan. 27, 1958.

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