This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (11)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

LEO J. CASS, M.D.; WILLEM S. FREDERIK, Ph.D., M.D.

AMA Arch Intern Med. 1958;102(4):571-579.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The problem of relating the effectiveness of the enormous number of new drugs now being produced by the pharmaceutical houses to existing medications is exceedingly difficult. It is, however, imperative that they be evaluated in this respect and that they be integrated correctly into the therapeutic armamentarium. The preliminary work begins with the chemist and the pharmacologist and proceeds to the physiologist, as well as to the field of animal experimentation. Throughout this period, new drugs are screened for toxic reaction and pharmacologic effect.

The obvious way to test the value of a medication is to give it to patients with the required symptoms and observe the results.¹ A strict procedure of checks and controls must be inaugurated and carried out, which will permit conclusions which are free of the variabilities of the subjective impression, except in cases where a medication produces a markedly obvious change, and even in . . . [Full Text PDF of this Article]

Author Affiliations
Cambridge, Mass.; Wellesley Hills, Mass.

University Health Services Harvard University (Dr. Cass); 20 Grantland Rd. (Dr. Frederik).

Footnotes
Submitted for publication Feb. 19, 1958.

This paper was adapted from a Scientific Exhibit presented at the 106th Annual Meeting of the American Medical Association, New York, June, 1957.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?