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Some Interrelations Between Sleep and Disease
EUGENE D. ROBIN, M.D.
AMA Arch Intern Med. 1958;102(4):669-675.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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There are a number of physiological differences between the sleeping and the waking state. The implications of these differences for the patient with disease have not been widely explored.
It is the purpose of this review to indicate by means of specific examples how some of the physiological changes associated with sleep may affect the pathologic physiology of some diseases. No attempt will be made to discuss every area in which it is known that the physiologic changes of sleep and disease overlap. Rather, this review will set forth some examples of mechanisms by which sleep may modify pathologic physiology. For this purpose, the following topics will be discussed:
- The basic nature of sleep
- Sleep and the control of ventilation
- Sleep and cardiovascular function
- Diurnal variation of adrenal function and its clinical significance
- Sleep and red cell metabolism in paroxysmal nocturnal hemoglobinuria
- Sleep and the host-parasite relation in filariasis
- Sleep
. . . [Full Text PDF of this Article]
Author Affiliations
Boston
Footnotes
Submitted for publication March 11, 1958.
From the Department of Medicine, Harvard Medical School, and the Medical Clinics of the Peter Bent Brigham Hospital. This investigation was supported in part by a research grant (H2243) from the National Heart Institute of the National Institutes of Health, Public Health Service, and in part by a grant from the Massachusetts Heart Association.
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