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R. J. WURTMAN, A.B.; M. M. FRANK, A.B.; M. D. ALTSCHULE, M.D.

AMA Arch Intern Med. 1958;102(5):790-794.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Oxidative processes in schizophrenia are currently being studied in many laboratories because some authors have speculated that hallucinations and other symptoms of schizophrenia might be caused by substances produced during possibly abnormal oxidation of epinephrine in schizophrenic patients. Akerfeldt¹ recently described a test that measures the oxidative power of serum; this test depends on the time that it takes for a red color to appear in serum after the addition of N,N'-dimethyl-pphenylenediamine, a substance that turns red when oxidized. Akerfeldt reported that serum from schizophrenic patients oxidized this substance very rapidly, whereas serum from normal subjects oxidized it slowly. However, he also noted that both normal pregnancy and chronic infection likewise caused abnormally rapid oxidation of N,N'dimethyl-p-phenylenediamine. Nevertheless, some observers have accepted the test as useful in the diagnosis of mental disease. On the other hand, Horwitt et al.² found the test to be without value, and Angel et al.³ . . . [Full Text PDF of this Article]

Author Affiliations
Waverley, Mass.

From the Laboratory of Clinical Physiology, McLean Hospital.

Footnotes
Submitted for publication March 11, 1958.

Aided by a grant from the Donner Foundation.

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