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Other Than Sulfonylurea Compounds

MARTIN G. GOLDNER, M.D.

AMA Arch Intern Med. 1958;102(5):830-840.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The successful introduction of the hypoglycemic sulfonylureas has aroused new interest in the attempts of the past to develop oral antidiabetic agents and has stimulated a new search for other substances with similar action. A historical review of this long series of failures and near successes would probably have little more than academic interest if it did not illustrate at the same time the vagaries of scientific progress. Discoveries usually lead to progress only if they are made at the right time. Commonly their acceptance depended on the readiness with which they can be integrated into prevalent thought, knowledge, and practice. The hypoglycemic sulfonylureas were discovered at such a fortuitous time. Even though originating from a chance observation, they were readily accepted because our concept and knowledge of diabetes had changed. A functional and multiple etiologic theory had replaced the old concept of an organic islet-cell deficiency. It had become . . . [Full Text PDF of this Article]

Author Affiliations
Brooklyn

Director of Medicine, Jewish Chronic Disease Hospital, Brooklyn, and Clinical Professor of Medicine, State University of New York College of Medicine, New York City.

Footnotes
Submitted for publication May 9, 1958.

Presented at the American Chemical Society, San Francisco, April 15, 1958.

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