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Nonmercurial Organic DiureticsTheir Action and Application
KARL H. BEYER, Jr., M.D., Ph.D.
AMA Arch Intern Med. 1958;102(6):1005-1015.
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The renotropic effect of diuretic agents is employed clinically to induce a more favorable balance between the glomerular filtration of plasma water and the reabsorption of "salt" and water by the renal tubules. As illustrated in Figure 1, it is attractive to consider that with the pathogenesis of cardiovascular-renal disease there may be phases of progressive imbalance between the reduction in glomerular filtration and the smaller diminution of tubule functional capacity that favors a relatively greater percentage reabsorption of electrolytes and water by the renal tubules. This process may be anticipated to contribute to an increasing percentage reabsorption of the glomerular filtrate leading to the accumulation of fluid in tissues and, ultimately, in body cavities.1,2 The same net effect would obtain under circumstances where glomerular filtration rate is not necessarily diminished but where there is more than commensurate reabsorption of electrolytes, as under the influence of increased production or
. . . [Full Text PDF of this Article]
Author Affiliations
West Point, Pa.
Merck Sharp and Dohme Research Laboratories.
Footnotes
Submitted for publication June 26, 1958.
Read in the Symposium on Recent Advances in the Knowledge of the Causes of Edema and in Diuretic Therapy before the Joint Meeting of the Section on Experimental Medicine and Therapeutics and the Section on Internal Medicine at the 107th Annual Meeting of the American Medical Association, San Francisco, June 26, 1958.
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