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The Role of Hemodialysis (Artificial Kidney) in Acute Poisoning
GEORGE E. SCHREINER, M.D.
AMA Arch Intern Med. 1958;102(6):896-913.
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The role of the artificial kidney in acute human poisoning may be considered in two distinct categories: (1) dialyzable poisons, wherein the rate of removal is critical to the welfare of the patient, and (2) nephrotoxic poisons, which produce damage to the kidneys and are not qualitatively different from other causes of acute renal insufficiency. In some instances, general toxicity may be produced from the poison itself, while in others it is a product of the uremic syndrome. It is the purpose of the present study to review eight years of experience with clinical dialyses in acute poisonings and to summarize related studies, with particular emphasis on the role of the artificial kidney in dialyzable poisons.
Dialyzable Poisons
The effective use of hemodialysis in any acute poisoning is based on the following assumptions:
- That the poison molecule can diffuse through cellophane from plasma water and has a reasonable removal rate,
. . . [Full Text PDF of this Article]
Author Affiliations
Washington, D. C.
From the Department of Medicine and the Renal Laboratory, Georgetown University School of Medicine.
Footnotes
Submitted for publication June 26, 1958.
The work of this Laboratory has been supported by grants from the Hartford Foundation, the Washington Heart Association, and the Georgetown Kidney Research Fund.
Read in the Symposium on the Clinical Application of the Artificial Kidney before the Section on Experimental Medicine and Therapeutics at the 107th Annual Meeting of the American Medical Association, San Francisco, June 26, 1958.
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