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Two Patients with Remission Associated with the Use of Large Amounts of Steroids

HERBERT A. BURKE, JR., M.D.; ROBERT C. HARTMANN, M.D.

AMA Arch Intern Med. 1959;103(1):105-112.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1954, Singer reviewed the subject of thrombotic thrombocytopenic purpura, collecting 55 cases from the literature.¹ Wile and Sturgeon, in 1956, compiled an additional 19 instances and added 3 case reports in children.² We are aware of an additional 25 reports during the years 1954-1957, bringing the total number of cases to over 100 ^3-27 In general the clinical course of this disorder has been most unfavorable, the majority of patients dying within eight weeks of the recognized onset of the disease. In rare instances survival for more than one year has been reported.^{23,24,26,28,29} Several of these patients had atypical manifestations, so that it is difficult to ascertain the time of onset of the disease and the survival time in all of these cases.

No well-documented typical case has undergone long-term spontaneous remission, and a variety of therapeutic endeavors has in general failed to influence the course . . . [Full Text PDF of this Article]

Author Affiliations
Nashville, Tenn.

From the Department of Medicine, Vanderbilt University School of Medicine and Hospital.

Footnotes
Submitted for publication Feb. 27, 1958.

Presented in part at the meeting of the American Society of Hematology, Atlantic City, N. J., April 26-27, 1958.

This study was supported by research Grant H-1435 from the Division of Research Grants and Fellowships, National Institutes of Health and by the John A. Hartford Foundation, Inc., New York.

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