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M. CLARK SILVERTHORNE, M.D.

AMA Arch Intern Med. 1959;103(1):133-139.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Novobiocin (Cathomycin), derived from the actinomycete Streptomyces spheroides, has now been added to the growing list of antibiotics useful in clinical medicine. Recent studies ^1-8 have shown this drug to be effective in infections due to many Gram-positive and a few Gram-negative organisms, and there has been particular interest in the demonstration that novobiocin is active against many strains of Staphylococcus.

The following case report illustrates the effectiveness of novobiocin used in the treatment of a patient with staphylococcal bacteremia and focal areas of osteomyelitis. In addition, the case is of interest because, while under treatment, the patient developed a reaction to the novobiocin, which subsided spontaneously despite the continued use of the drug.

Report of Case

The patient, a 58-year-old white man, was admitted to the Medical Service of the McKinney Veterans' Administration Hospital for the fourth time on Dec. 31, 1955, complaining chiefly of intermittent feverishness, chilly sensations, . . . [Full Text PDF of this Article]

Author Affiliations
Denton, Texas

From the Medical Service, Veterans' Administration Hospital, McKinney, Texas.

Footnotes
Submitted for publication Feb. 27, 1958.

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