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A Controlled Study of the Effects of Tetracycline, Penicillin, and an Oleandomycin-Penicillin Mixture

NEIL S. CHERNIACK, M.D.; KENNETH L. VOSTI, M.D.; HARRY F. DOWLING, M.D.; MARK H. LEPPER, M.D.; GEORGE GEE JACKSON, M.D.

AMA Arch Intern Med. 1959;103(3):345-353.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Several antibiotics are effective in the treatment of acute bacterial infections of the lower respiratory tract in patients with chronic bronchitis and bronchiectasis. However, studies designed to test the effectiveness of antibiotics in treating the low-grade, continuing infection in patients with these diseases and in preventing acute infections of the lower respiratory tract in these patients have had contradictory results.

Penicillin was used extensively both systemically and by aerosol in the years immediately following its introduction. Comprehensive reports have been made by Barach and his associates ¹ and by Finke.² Penicillin was never successful in eradicating Hemophilus influenzae, which Mulder and his associates ³ and others ^4,5 believe to be the most important pathogenic agent in bronchiectasis and chronic bronchitis, and in recent years the increasing prevalence of penicillin-resistant staphylococci have further limited the effectiveness of penicillin.

Mulder and his associates³ reported excellent results in chronic bronchitis when . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the University of Illinois Research and Educational Hospitals and the Departments of Medicine and Preventive Medicine, University of Illinois College of Medicine.

Footnotes
Submitted for publication Aug. 20, 1958.

This investigation was supported in part by a Research Grant E-1690 from the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health, Public Health Service, and by grants from the Tuberculosis Institute of Chicago and Cook County, Chas. Pfizer & Company, Inc., and Lederle Laboratories Division, American Cyanamid Company.

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