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CAPT. WALTER H. WHITCOMB, MC; ROBERT M. BIRD, M.D.; PHILIP C. JOHNSON, M.D.; JAMES F. HAMMARSTEN, M.D.; MARGARET MOORE, B.S.

AMA Arch Intern Med. 1959;103(6):871-875.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Many patients with chronic hypoxia due to pulmonary emphysema fail to develop a secondary polycythemia.^1,2 When polycythemia does occur in such patients it is often less than that which a normal person would develop if exposed to a similar degree of hypoxia.³ Many have sought an explanation for this unresponsiveness of the emphysematous patient to the hypoxic stimulus. There is agreement that some emphysematous patients fail to develop polycythemia owing to a failure of erythropoiesis.² Although such patients frequently have chronic pulmonary infections, a critical study of their hemopoietic dynamics does not yield information similar to that found in the anemia of infection.^2,4 There is increasing evidence to suggest that the hypoxic stimulus to erythropoiesis is mediated by a humoral factor, erythropoietin.^5-7 The biological assay of this humoral factor in the plasma of unresponsive patients with emphysema has not been documented.

The present report is concerned with the assay for . . . [Full Text PDF of this Article]

Author Affiliations
U. S. A. F.; Oklahoma City

From the Radioisotope Service and Department of Medicine, Veterans Administration Hospital, and the University of Oklahoma School of Medicine and Hospitals, Oklahoma City.

Footnotes
Submitted for publication Oct. 13, 1958.

An abstract of this paper appeared in the Proceedings of the Central Society for Clinical Research (Clin. Res. 5:390, 1958).

This investigation was supported in part by a graduate training grant (2A-5107) from the National Institutes of Arthritis and Metabolic Diseases, U. S. Public Health Service.

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