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HENRY B. BRUYN, M.D.; EDWIN H. LENNETTE, M.D.

AMA Arch Intern Med. 1959;103(6):914-923.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The characteristic ability of influenza viruses to undergo variation in antigenic structure has given rise to a new family of influenza A strains, now officially referred to as the "Asian family." ¹ With the first recognized appearance and isolation of this new virus, early in 1957, and the decision to develop vaccines for active immunization against this new antigenic variant,² emphasis was placed anew on problems which required a review of our previous knowledge of the antigenic behavior of Type A influenza viruses as well as of the immunologic response in man when exposed to new variants of the Type A group of viruses.

Early studies on antigenic variants of influenza A viruses showed that protection induced by active immunization was greatest against the homologous virus strain and that the efficacy of immunization against heterologous strains depended upon antigenic relationships between the immunizing and the infecting virus strains.³ . . . [Full Text PDF of this Article]

Author Affiliations
Berkeley, Calif.; With the Technical Assistance of Florence W. Jensen, B.A., and Lorraine Tauber, M.A.

From the Department of Pediatrics, University of California Medical Center, San Francisco, the Viral and Rickettsial Disease Laboratory, California State Department of Public Health, Berkeley, and the Infectious Disease Laboratory, San Francisco Hospital.

Footnotes
Submitted for publication Aug. 25, 1958.

This study was supported by a research contract (SAph 69479) from the Communicable Disease Center, Public Health Service; by a grant (E-1475) from the National Institute of Allergy and Infectious Diseases, Public Health Service, to the Viral and Rickettsial Disease Laboratory, and by a grant from the Research Committee of the University of California.

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