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S. D. YEH, M.D.; W. F. SEIP, B.S.; C. BURCH, A.B.; F. W. BARNES, Jr., M.D.

AMA Arch Intern Med. 1959;103(6):933-948.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

Serum proteins incorporate amino acids very rapidly, and it seems justifiable to conclude that this process takes place within cells somewhere in the body, whether by synthesis de novo or by some sort of exchange in the cell between serum proteins and amino acids. Implicit in the latter is the assumption that circulating serum proteins continuously return to cells of origin. In recent years it has been found that serum proteins do indeed pass from the blood stream into cells of many of the body tissues ^{1,4,7,9,10,16,17,21,26,28,31,32,34,39} Also, recent evidence indicates that serum proteins are utilized metabolically by cells. Both albumins and globulins appear to be involved in these cellular relationships.^39-41

On the other hand, proteins of many kinds are elaborated by body tissues and appear in various extracellular fluids. The serum proteins, composed of a number of different molecular species, represent at least a considerable fraction of . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore With the Aid of R. Rutherford, M.D.

From the Departments of Medicine and of Physiological Chemistry, The Johns Hopkins University School of Medicine.

Footnotes
Submitted for publication Aug. 8, 1958.

These results were presented in part at the meeting of the Council for Research in Plastic Surgery, September, 1955, Baltimore. They were further described in abstract form at the meeting of the Society for Pediatric Research, Buck Hill Falls, Pa., May 7-8, 1956 (A.M. A. J. Dis. Child. 93:60, 1957).

This investigation was supported by research grants from the Tobacco Industry Research Committee; The American Cancer Society, Inc.; The American Heart Association, Inc.; The American Cancer Society, Maryland Division; The U. S. Public Health Service, National Institutes of Health; The Damon Runyon Memorial Fund for Cancer Research; The Milton M. Frank Foundation, and The Noxzema Corporation.

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