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H. L. MOLLERBERG, M.D.; L. E. BÖTTIGER, M.D.

AMA Arch Intern Med. 1959;103(6):949-953.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1951, Siede and Strohm ¹ suggested a liver-function test with a sulfonamide preparation, the red dye azosulfamide (Prontosil Soluble, Bayer, or Neoprontosil, Winthrop). Azosulfamide is a sodium salt of an azo compound between sulfanilamide and a hydroxynaphthaline sulfonic acid with the formula shown in Figure 1.

About one-half of the administered dose is taken up by the liver cells. Part of this is then excreted unchanged in the bile,² whereas the rest is broken down, probably by reductive enzymes.³ One of the metabolites seems to be sulfanilamide.⁴

The remainder of the azosulfamide, i. e., the part not removed by the liver, is excreted unchanged in the urine. The elimination occurs chiefly during the first 5 to 6 hours after the injection and is completed within 24 hours. The total amount of azosulfamide eliminated in the urine gives an indirect measure of the liver function with regard . . . [Full Text PDF of this Article]

Author Affiliations
Stockholm, Sweden

From the Department of Clinical Biochemistry, Karolinska Sjukhuset.

Footnotes
Submitted for publication July 29, 1958.

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